Guaireña FC, sitting in 10th place with 32 points, is set to take on league leaders Club Rubio Ñu, who have an impressive 56 points.
Guaireña FC has lost half of their last six home games in Division Intermedia, while Club Rubio Ñu has secured wins in 16 of their last 27 matches.
Historically, Guaireña FC has struggled against Club Rubio Ñu, suffering three defeats in their last six meetings.