Club Universidad Nacional vs. Atletico de San Luis Prediction, Match Preview and Betting Tips, 23 October 2025

The upcoming clash between Club Universidad Nacional and Atletico de San Luis on 23 October 2025 in Liga MX is more than just another league fixture. With Universidad Nacional sitting in 10th place with 14 points and Atletico de San Luis right behind them at 11th with 13 points, this match is pivotal in the race for higher standings.

Pumas UNAM, playing at home at Olímpico Universitario, are the favourites with odds of 1.77 to win. Despite their recent form of Draw-Loss-Loss-Loss-Draw, their historical head-to-head advantage over San Luis, having won four of their last five meetings, adds weight to their confidence.

San Luis, under Guillermo Abascal, has shown inconsistency (Win-Loss-Loss-Loss-Win). With key absences like César Iván López and potential doubts over Óscar Macías, Pumas could capitalize on this. Meanwhile, João Pedro, San Luis’s top scorer with nine goals, will aim to exploit Pumas’ defense, which concedes an average of 1.5 goals per match.

Our match tip: Universidad Nacional to win, leveraging their strong home record and recent form against San Luis.

Club Universidad Nacional vs Atletico de San Luis Prediction & Betting Tip

Club Universidad Nacional vs Atletico de San Luis Prediction
Betting Tip
Pumas UNAM to Win (Odds: 1.77)

Pumas UNAM are recommended to win this fixture, and here’s why:

• Head-to-Head Advantage: Pumas UNAM have won four of their last five meetings against Atletico de San Luis, showcasing a strong psychological edge.
• Home Advantage: Playing at the Estadio Olímpico Universitario has proven beneficial for Pumas, especially considering San Luis’s inconsistency on the road.
• Current Form: Despite recent struggles, Pumas remain in slightly better form with the chance to leapfrog into higher standings, making this a crucial match.

The historical dominance, coupled with the home field advantage and relatively generous odds, makes backing Pumas UNAM a valuable bet.

Club Universidad Nacional vs Atletico de San Luis Odds

The odds for the upcoming Liga MX match between Pumas UNAM and Atletico de San Luis highlight an intriguing betting landscape. Pumas UNAM, playing at home, are the bookmaker favorites with attractive odds, suggesting higher confidence in their victory.

Club Universidad Nacional vs Atletico de San Luis Betting Odds
Bet	Odds
Club Universidad Nacional to Win	1.77
Draw	3.71
Atletico de San Luis to Win	3.95

With Club Universidad Nacional’s strong head-to-head record against Atletico de San Luis and playing at their home venue, the odds reflect their potential to secure a win. Despite recent form dips, Pumas UNAM’s historical dominance over San Luis makes the 1.77 odds for a home victory particularly enticing for bettors.

Club Universidad Nacional Team Analysis

Club Universidad Nacional Recent Performance

Pumas UNAM have been struggling in their recent fixtures, as shown by their last five results:

• Monterrey 1-1 Club Universidad Nacional
• Club Universidad Nacional 1-2 CD Guadalajara
• CF América 4-1 Club Universidad Nacional
• FC Juárez 3-1 Club Universidad Nacional
• Club Universidad Nacional 1-1 Tigres

Recent form: Draw-Loss-Loss-Loss-Draw

Despite their challenges, Pumas have managed to score an average of 1.00 goals per game over the last five matches. However, defensively they’ve been porous, failing to keep a clean sheet in the same period. The defensive line, led by Keylor Navas, will need to step up to shore up this vulnerability.

The influence of top scorer Guillermo Martínez, although injured, has been felt, and the team will need others to step up in his absence to convert their chances into goals. They currently sit 10th in the league standings, making this upcoming match a crucial opportunity to improve their position.

Club Universidad Nacional Key Players

For Club Universidad Nacional, the absence of top scorer Guillermo Martínez, who has netted 4 goals this season, will indeed be felt. However, other key players are expected to step up in this critical fixture against Atletico de San Luis.

Key Players:

• José Juan Macías: Leading the attack, Macías will be looking to fill the scoring void left by Martínez.
• Alan Medina: Deployed on the right wing, Medina’s pace and crossing ability can be decisive.
• Adalberto Carrasquilla: Operating as the attacking midfielder, Carrasquilla’s vision and playmaking will be crucial in breaking down San Luis’s defense.

Expected lineup for Club Universidad Nacional:

• Goalkeeper: Keylor Navas
• Defenders: Pablo Bennevendo, Ángel Azuaje, Nathan Silva, Álvaro Angulo
• Midfielders: José Caicedo, Pedro Vite, Alan Medina, Adalberto Carrasquilla, Jorge Ruvalcaba
• Forward: José Juan Macías

These players will play pivotal roles, particularly in defense against San Luis’s top scorer João Pedro, who’ll provide a stern test for the backline.

Club Universidad Nacional Suspensions & Injuries

Club Universidad Nacional will face Atletico de San Luis without their key player Guillermo Martínez Ayala, who is sidelined with a foot injury and is expected to return only in early January 2026. Additionally, Aaron Ramsey is dealing with physical discomfort and is likely to miss around a week.

The absence of Martínez Ayala, their top scorer with 4 goals this season, is a significant blow to their attacking force. This puts additional pressure on José Juan Macías and other forward players to step up and fill the void. Ramsey’s absence in midfield could also affect their control and distribution of the ball.

With a weakened squad, Pumas will need their remaining core players to perform at their best to secure a critical win in this match.

Club Universidad Nacional Tactics and Formation

For the upcoming match against Atletico de San Luis, Club Universidad Nacional is likely to adopt a tactic-focused 4-2-3-1 formation.

Tactical Breakdown:

• Formation: 4-2-3-1
• Key Forward: José Juan Macías – Expected to lead the attacking line and exploit any defensive weaknesses in the opposition.
• Midfield Trio: Alan Medina (right wing), Adalberto Carrasquilla (attacking midfielder), Jorge Ruvalcaba (left wing) – Responsible for creating chances and maintaining possession in the middle third.
• Defensive Setup:
• Defensive Midfield Pair: José Caicedo and Pedro Vite – Expected to shield the backline and disrupt opposition attacks.
• Back Four: Pablo Bennevendo, Ángel Azuaje, Nathan Silva, Álvaro Angulo – Tasked with maintaining a structured defensive line, especially crucial given their recent difficulties in keeping clean sheets.
• Goalkeeper: Keylor Navas – An experienced presence between the sticks expected to guide the defense.

Notable Strategy:

• Emphasize quick transitions from defense to attack to leverage their pace on the wings and catch San Luis off guard.

The 4-2-3-1 setup will aim to provide balance, allowing Pumas to defend solidly and spring quick, efficient attacks.

Atletico de San Luis Team Analysis

Atletico de San Luis Recent Performance

Atletico de San Luis have demonstrated mixed form in their last five matches, achieving two wins and three losses:

• Atletico de San Luis 2-0 Atlas
• Mazatlán FC 2-1 Atletico de San Luis
• Pachuca 2-1 Atletico de San Luis
• Atletico de San Luis 0-1 CF América
• Santos Laguna 1-4 Atletico de San Luis

Recent form: Win-Loss-Loss-Loss-Win

San Luis has shown a stronger offensive edge, scoring an average of 1.60 goals per game in their last five fixtures. They have, however, managed only one clean sheet in this duration, highlighting some defensive vulnerabilities. Currently sitting 11th in the standings with 13 points, this upcoming match is pivotal for them to close the gap and climb higher.

Coached by Guillermo Abascal, San Luis will rely heavily on their top scorer João Pedro, who has netted 9 goals this season, to breach Pumas’ defense. Their inconsistency on the road, however, remains a challenge they will need to address.

Atletico de San Luis Key Players

Atletico de San Luis will look to their standout performers to spearhead a challenge against Club Universidad Nacional.

Key Players:

• João Pedro: With 9 goals this season, he is the most lethal weapon in San Luis’s arsenal and a constant threat to any defense.
• Benjamin Galdames: Playing on the right wing, Galdames’s pace and dribbling skills can create numerous opportunities.
• Sebastián Pérez Bouquet: As the attacking midfielder, Pérez Bouquet’s role in linking the midfield with the attack will be crucial in orchestrating San Luis’s offensive moves.

Expected lineup for Atletico de San Luis:

• Goalkeeper: Andrés Sánchez
• Defenders: Román Torres, Robson Bambu, Eduardo Águila, Juan Manuel Sanabria
• Midfielders: Sébastien Salles Lamonge, Rodrigo Dourado, Benjamin Galdames, Sebastián Pérez Bouquet, Miguel García
• Forward: João Pedro

The individual battle between João Pedro and Pumas’ defensive unit, especially Keylor Navas in goal, will be crucial in determining the match’s outcome.

Atletico de San Luis Suspensions & Injuries

Atletico de San Luis is heading into this crucial encounter with a few injury concerns that might influence their performance. César Iván López is out with a cruciate ligament injury and is not expected to return until mid-April 2026. Additionally, both Juanpe and Óscar Macías are doubtful due to knock and knee injuries, respectively.

The absence of César Iván López weakens their defensive stability, and should both Juanpe and Macías miss the match, the midfield and offensive buildup may suffer significantly. Coach Guillermo Abascal will need to rely on his available players to step up and cover these critical absences to hold their own against a formidable Pumas UNAM side at the Olímpico Universitario.

Atletico de San Luis Tactics and Formation

For the upcoming battle against Club Universidad Nacional, Atletico de San Luis is expected to line up in a tactically disciplined 4-2-3-1 formation.

Tactical Breakdown:

• Formation: 4-2-3-1
• Key Forward: João Pedro – As the top scorer, he will be the focal point of their attack, aiming to exploit any gaps in Pumas’ defense.
• Midfield Trio: Benjamin Galdames (right wing), Sebastián Pérez Bouquet (attacking midfielder), Miguel García (left wing) – This trio will be vital for creating scoring opportunities and maintaining offensive pressure.
• Defensive Midfield Pair: Sébastien Salles Lamonge and Rodrigo Dourado – Tasked with defensive duties and disrupting Pumas’ attacking plays to protect their backline.
• Back Four: Román Torres, Robson Bambu, Eduardo Águila, Juan Manuel Sanabria – Expected to provide a solid and cohesive defensive line to mitigate high-impact plays from Pumas.
• Goalkeeper: Andrés Sánchez – Responsible for organizing the defense and making crucial saves.

Notable Strategy:

• Utilize speedy counter-attacks to catch Pumas on the break, leveraging the pace of their wingers and João Pedro’s finishing ability.

This balance between defensive solidity and quick offensive transitions will be central to San Luis’s game plan.

Club Universidad Nacional vs Atletico de San Luis Head-to-Head Statistics

The recent head-to-head encounters between Club Universidad Nacional and Atletico de San Luis provide intriguing insights leading into their next clash. Over the last five meetings, Club Universidad Nacional has emerged victorious four times, highlighting their dominance:

• 2025-02-03: Atletico de San Luis 2-3 Club Universidad Nacional (Liga MX Clausura)
• 2024-10-20: Club Universidad Nacional 3-0 Atletico de San Luis (Liga MX Apertura)
• 2024-01-20: Atletico de San Luis 3-1 Club Universidad Nacional (Liga MX Clausura)
• 2023-09-17: Club Universidad Nacional 3-2 Atletico de San Luis (Liga MX Apertura)
• 2023-04-09: Club Universidad Nacional 3-1 Atletico de San Luis (Liga MX Clausura)

These recent results showcase a strong track record for Pumas UNAM, especially when playing at the Estadio Olímpico Universitario. This consistent dominance can give them a psychological edge in the upcoming fixture. With both teams close in the standings, this head-to-head history suggests a favorable outcome for Club Universidad Nacional.

Odds accurate as of 21 October 2025 04:06, and are subject to change. Please always check the odds before placing your bets with any bookmaker.