Mazatlan FC vs. Santos Laguna Prediction, Match Preview and Betting Tips, 22 October 2025

Mazatlan FC and Santos Laguna clash in an intriguing Liga MX encounter at Estadio El Encanto on 22 October 2025. Despite being lower in the standings, Mazatlan FC (15th with 11 points) is marginally ahead in form compared to Santos Laguna (12th with 13 points).

Mazatlan FC, struggling with key player injuries, has shown a pattern of high-scoring games at home. In contrast, Santos Laguna has been inconsistent but boasts a slightly better defensive record recently with two clean sheets in their last five games.

Given both teams’ recent form and defensive challenges, our match tips recommend betting on over 2.5 goals. This encounter promises an open, attack-oriented affair, accentuated by their historical matchups and current needy standings.

Expect key contributions from Mazatlan FC’s top scorer Nicolas Benedetti and Santos Laguna’s frontman Cristian Dajome in what should be an exciting and crucial match for both sides’ playoff hopes.

Mazatlan FC vs Santos Laguna Prediction & Betting Tip

Mazatlan FC vs Santos Laguna Prediction
Betting Tip
Over 2.5 Goals – Odds: 1.85

Mazatlan FC taking on Santos Laguna is set to be a thrilling encounter. Our top betting tip is to back Over 2.5 Goals. Here’s why:

• Mazatlan FC’s recent home games have consistently hit the over 2.5 goals mark, with 80% of their matches ending with high scores.
• The historical matchups between these teams often see plenty of action, including a 3-1 win and a 1-1 draw.
• Both sides are dealing with key injuries—Mazatlan’s midfield is particularly affected, and Santos Laguna are missing defensive stalwart Matheus Doria, paving the way for more goal-scoring opportunities.

Given these factors, expect a lot of goals in what should be an exciting clash at Estadio El Encanto.

Mazatlan FC vs Santos Laguna Odds

Mazatlan FC is the bookmaker’s favourite for this Liga MX clash against Santos Laguna. The odds reflect their slightly better form and home advantage. Let’s break it down:

Mazatlan FC vs Santos Laguna Betting Odds
Bet	Odds
Mazatlan FC	1.86
Draw	3.67
Santos Laguna	3.63

Mazatlan FC’s odds of 1.86 suggest a favourable chance of victory, given their tendency for high-scoring home matches and relatively better position in recent results.

However, Santos Laguna is not far behind with odds of 3.63, indicating that this game could swing either way. The draw at 3.67 presents a viable option too, considering the historical records between these teams, which often result in closely contested matches.

Mazatlan FC Team Analysis

Mazatlan FC Recent Performance

Mazatlan FC’s recent form has been inconsistent, as shown by their DDLWL record in the last five matches. They suffered a 2-0 away defeat against CD Guadalajara but managed a crucial 2-1 home win over Atletico de San Luis. Unfortunately, consistency remains an issue with a 3-1 loss to Toluca and a 2-2 draw with Leon.

Recent Form Highlights:

• Mazatlan FC has failed to secure a clean sheet in their last five games.
• They have averaged 1.20 goals per game over this period.
• Defensively, they are leaking goals with an average of 1.8 goals conceded per match this season.
• Their games are often high-scoring, making them entertaining to watch.

Mazatlan’s home advantage could be pivotal, but their leaky defense remains a concern heading into this crucial matchup.

Mazatlan FC Key Players

Mazatlan FC’s attacking prowess will rely heavily on Nicolas Benedetti, currently their top scorer with three goals this season. However, his participation is uncertain due to a knock injury, which could impact their offensive capabilities.

Another key player is Daniel Gutierrez, their reliable goalkeeper expected to start. His role will be crucial in organizing the defence given Mazatlan’s inability to keep clean sheets in recent games.

Ivan Gonzalez and Fabio Gomes, who are in the likely starting lineup, are also expected to contribute significantly in attack, looking to exploit Santos Laguna’s defensive vulnerabilities.

Expected lineup for Mazatlan FC:

• Goalkeeper: Daniel Gutierrez
• Defenders: Angel Leyva, Facundo Almada, Roberto Meraz
• Midfielders: Yoel Barcenas, Jose Esquivel, Bryan Colula, Mauro Zaleta
• Forwards: Dudu Teodora, Fabio Gomes, Ivan Gonzalez

Key individual battles will likely include Benedetti or Gomes vs Santos Laguna’s defence, which could be a deciding factor in the match.

Mazatlan FC Suspensions & Injuries

Mazatlan FC is facing significant injury concerns ahead of their clash with Santos Laguna. Key players like Nicolas Benedetti (knock), Alberto Herrera (knee), Jefferson Intriago (hamstring), and Omar Moreno (knock) are all doubtful for this match. These injuries could heavily impact the team’s performance, especially in midfield and attack.

Benedetti’s potential absence would be a significant blow, considering he is the team’s top scorer with three goals this season. His creativity and goal-scoring ability will be hard to replace.

The midfield, already thin with injuries to Intriago and Moreno, might struggle to control the game, potentially exposing their defence even more. Herrera’s experience at the back will also be missed if he fails to recover in time.

These absences might push the coach to rethink his tactics and rely on less experienced players, posing a challenging situation for Mazatlan FC.

Mazatlan FC Tactics and Formation

Mazatlan FC Tactical Breakdown:

• Formation: 3-4-3
• Key Forward: Nicolas Benedetti (if fit)
• Midfield Duo: Jose Esquivel and Bryan Colula
• Defensive Line: Angel Leyva, Facundo Almada, Roberto Meraz
• Notable Strategy: High-pressing style with an emphasis on wide play, capitalizing on crosses into the box from the flanks.

Mazatlan FC usually employs a 3-4-3 formation, focusing on aggressive attacking play primarily through their wingers. With key players in the midfield like Esquivel and Colula, they aim to control the tempo of the game, though recent injuries may require a tactical rethink.

Defensively, the team has struggled, failing to keep any clean sheets in their last five games, and conceding an average of 1.8 goals per match this season. Their high press often leaves them vulnerable to counter-attacks, so filling the midfield gaps left by injured players will be crucial.

The aggressive approach and dynamic forward play make Mazatlan’s matches high-scoring and entertaining.

Santos Laguna Team Analysis

Santos Laguna Recent Performance

Santos Laguna’s form has been mixed, as depicted by their LWLLW record in the last five matches. They managed a 2-0 home victory against Leon but suffered notable defeats, including a 3-0 loss to CF America and a 1-0 to Monterrey.

Recent Form Highlights:

• Santos Laguna has kept two clean sheets in their last five games, indicating some defensive resilience.
• They have averaged 0.80 goals per game over this period, showing struggles in front of goal.
• Conversely, their defensive record is slightly better than Mazatlan’s, conceding an average of 1.6 goals per match this season.

Consistency remains an area for improvement, but their recent clean sheet against Leon could provide a morale boost as they aim to climb up the standings. The upcoming game offers them a critical opportunity to regain their footing in the league.

Santos Laguna Key Players

Santos Laguna will lean heavily on their top scorer, Cristian Dajome, who has tallied four goals this season. His performance will be crucial for breaking down Mazatlan’s defence, especially considering their opponent’s vulnerability at the back.

Another key figure is goalkeeper Carlos Acevedo, who has been consistent between the sticks, contributing to their two clean sheets in the last five games. His form will be a significant factor in limiting Mazatlan’s attacking threats.

Expected lineup for Santos Laguna:

• Goalkeeper: Carlos Acevedo
• Defenders: Jose Abella, Kevin Balanta, Oscar Ortega, Bruno Amione
• Midfielders: Salvador Mariscal, Ramiro Sordo, Fran Villalba, Javier Guemez, Kevin Palacios
• Forward: Bruno Barticciotto

Key individual battles will likely include Dajome’s offensive prowess against Mazatlan’s defence, an area where Santos Laguna can exploit and gain an advantage.

Santos Laguna Suspensions & Injuries

Currently, Santos Laguna does not have any players under suspension, giving them a full squad to select from. This is crucial as it means the team will be at full strength, potentially increasing their chances of putting up a strong performance against Mazatlan FC.

Given their recent struggles in scoring and the importance of maintaining defensive solidity, having all key players available could provide a much-needed boost. This could especially aid their bid to improve consistency, an area that has plagued them in recent matches.

Overall, with a complete roster available, Santos Laguna will look to leverage this advantage to secure a positive result in this critical Liga MX encounter.

Santos Laguna Tactics and Formation

Santos Laguna Tactical Breakdown:

• Formation: 4-1-4-1
• Key Forward: Cristian Dajome
• Midfield Anchors: Fran Villalba and Javier Guemez
• Defensive Backbone: Goalkeeper Carlos Acevedo

Santos Laguna typically deploys a 4-1-4-1 formation, aiming to create a balanced structure that facilitates both defensive solidity and attacking fluidity. Cristian Dajome, their top scorer, operates as the principal attacking threat, while Fran Villalba and Javier Guemez provide the key midfield support, ensuring ball retention and distribution.

Defensively, Carlos Acevedo’s presence in goal provides a reliable last line of defence, as evidenced by their two clean sheets in the last five games. Santos focuses on maintaining positional discipline, while looking to exploit counter-attacking opportunities, especially during periods when Mazatlan’s high press might leave them exposed.

Expect a disciplined, yet opportunistic approach from Santos Laguna as they aim to improve their scoring output and climb the standings.

Mazatlan FC vs Santos Laguna Head-to-Head Statistics

These two teams have met five times in recent Liga MX seasons, creating a keenly contested rivalry. The results from their last five encounters are as follows:

Previous Matches:

• 2025-02-15: Mazatlan FC 1-1 Santos Laguna
• 2024-10-26: Santos Laguna 0-0 Mazatlan FC
• 2024-02-26: Santos Laguna 1-0 Mazatlan FC
• 2023-11-24: Santos Laguna 2-1 Mazatlan FC (Apertura Play-In Stage)
• 2023-11-02: Mazatlan FC 3-1 Santos Laguna

Analysis:

• Recent Dominance: Santos Laguna has a slight edge, with two wins and two draws in the last five games against Mazatlan FC.
• Goal Distribution: Only the most recent games have seen a higher goal tally, such as Mazatlan’s 3-1 win, indicating a pattern of generally tight matches.
• Home Advantage: Mazatlan FC has had mixed results at home, displaying both resilience and vulnerability.

Overall, the head-to-head stats suggest a closely fought contest with potential for goals, aligning well with our betting tip of over 2.5 goals.

Odds accurate as of 20/10/2025 04:01, and are subject to change. Please always check the odds before placing your bets with any bookmaker.